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학       력
1996.02.15 한국과학기술원  이학박사
1992.02.22 한국과학기술원  이학석사
1990.02.24 고려대학교  이학사
연구실적
<논문> 
Upregulation of microRNA-1246 Is Associated with BRAF Inhibitor Resistance in Melanoma Cells with Mutant BRAF, Cancer Research and Treatment , 제49권(집) , 제4호 , PP.947~959 , 2017.10.01
Cytoprotective role of autophagy against BH3 mimetic gossypol in ATG5 knockout cells generated by CRISPR-Cas9 endonuclease, CANCER LETTERS , 제270권(집) , PP.19~26 , 2016.04.29
Paclitaxel-induced G2/M Arrest via Different Mechanism of Actions in Glioma Cell Lines with Differing p53 Mutational Status, International Journal of Pharmacology , PP.19~27 , 2016.04.29
Suppression of lytic replication of Kaposi’s sarcoma-associated herpesvirus by autophagy during initial infection in NIH 3T3 fibroblasts, ARCHIVES OF VIROLOGY , 제161권(집) , 제3호 , PP.595~604 , 2016.03.01
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition), Autophagy , 제12권(집) , 제1호 , PP.1~222 , 2016.01.02
Low inducible expression of p21Cip1 confers resistance to paclitaxel in BRAF mutant melanoma cells with acquired resistance to BRAF inhibitor, MOLECULAR AND CELLULAR BIOCHEMISTRY , 제406권(집) , 제1호 , PP.53~62 , 2015.08.01
Induction of Resistance to BRAF Inhibitor Is Associated with the Inability of Spry2 to Inhibit BRAF-V600E Activity in BRAF Mutant Cells, Biomolecules & Therapeutics , 제23권(집) , 제4호 , PP.320~326 , 2015.04.30
The siRNA-mediated downregulation of N-Ras sensitizes human melanoma cells to apoptosis induced by selective BRAF inhibitors, MOLECULAR AND CELLULAR BIOCHEMISTRY , 제392권(집) , PP.239~247 , 2014.07.01
Autophagy-mediated growth inhibition of malignant glioma cell by the BH3-mimetic gossypol, Molecular & Cellular Toxicology , 제10권(집) , 제2호 , PP.157~164 , 2014.06.30
The pro-death role of autophagy and apoptosis in cell death induced by the BH3 mimetic gossypol, ANIMAL CELLS AND SYSTEMS , 제18권(집) , 제3호 , PP.183~189 , 2014.06.02
Oncogenic BRAF inhibitor UAI-201 induces cell cycle arrest and autophagy in BRAF mutant glioma cells, LIFE SCIENCES , 제104권(집) , 제1호 , PP.38~46 , 2014.05.28
BH3-mimetic gossypol-induced autophagic cell death in mutant BRAF melanoma cells with high expression of p21(CiP1), LIFE SCIENCES , 제102권(집) , 제1호 , PP.41~48 , 2014.04.25
Genotoxicity assessment of erythritol by using short-term assay, Toxicological Research , 제29권(집) , 제4호 , PP.249~255 , 2013.12.31
Defective autophagy in multidrug resistant cells may lead to growth inhibition by BH3-mimetic gossypol, JOURNAL OF CELLULAR PHYSIOLOGY , 제228권(집) , 제7호 , PP.1496~1505 , 2013.07.01
Autophagy-Dependent Survival of Mutant B-Raf Melanoma Cells Selected for Resistance to Apoptosis Induced by Inhibitors against Oncogenic B-Raf, BIOMOLECULES THERAPEUTICS , 제21권(집) , 제2호 , PP.114~120 , 2013.03.31
Differential inhibitory effects of two Raf-targeting drugs, sorafenib and PLX4720, on the growth of multidrug-resistant cells, MOLECULAR AND CELLULAR BIOCHEMISTRY , 제372권(집) , 제1호 , PP.65~74 , 2013.01.01
Src Family Kinase Inhibitor PP2 Induces LC3 Conversion in a Manner That is Uncoupled from Autophagy and Increases Apoptosis in Multidrug-Resistant Cells, BIOMOLECULES THERAPEUTICS , 제20권(집) , 제4호 , PP.393~398 , 2012.07.31
Differential sensitivity of melanoma cell lines with differing B-Raf mutational status to the new oncogenic B-Raf kinase inhibitor UI-152, CANCER LETTERS , 제320권(집) , 제2호 , PP.215~224 , 2012.07.28
Guidelines for the use and interpretation of assays for monitoring autophagy, Autophagy , 제8권(집) , 제4호 , PP.445~544 , 2012.05.01
The role of autophagy in cytotoxicity induced by new oncogenic B-Raf inhibitor UI-152 in v-Ha-ras transformed fibroblasts, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS , 제417권(집) , 제2호 , PP.857~863 , 2012.01.13
Suppression of autophagy sensitizes multidrug resistant cells towards Src tyrosine kinase specific inhibitor PP2, CANCER LETTERS , 제310권(집) , 제2호 , PP.188~197 , 2011.11.28
Decreased interaction of Raf-1 with its negative regulator Spry2 as a mechanism for acquired drug resistance, Biomolecules & Therapeutics , 제19권(집) , 제2호 , PP.174~180 , 2011.04.01
Targeting the autophagy pathway using ectopic expression of Beclin 1 in combination with rapamycin in drug-resistant v-Ha-ras-transformed NIH3T3 cells, MOLECULES AND CELLS , 제31권(집) , 제3호 , PP.231~238 , 2011.03.31
Crosstalk between autophagy and apoptosis in the regulation of paclitaxel-induced cell death in v-Ha-ras-transformed fibroblasts, MOLECULAR AND CELLULAR BIOCHEMISTRY , 제348권(집) , 제1-2호 , PP.61~68 , 2011.02.01
Assessment of the dermal and ocular irritation potential of alcohol hand sanitizer containing aloe vera with in vitro and in vivo methods, Molecular & Cellular Toxicology , 제6권(집) , 제4호 , PP.401~408 , 2010.12.31
Genotoxicity studies on HM10760A, recombinant human erythropoietin conjugated to globin fragment, Drug and Chemical Toxicology , 제33권(집) , 제2호 , PP.152~159 , 2010.04.01
Assessment of the Dermal and Ocular Irritation Potential of Lomefloxacin by Using In Vitro Methods, 한국독성학회지 , 제26권(집) , 제1호 , PP.9~14 , 2010.04.01
Spry2 interaction does not directly modulate Raf-1 kinase activity in v-H-ras transformed NIH3T3 fibroblasts, BMB Reports , 제43권(집) , 제3호 , PP.205~211 , 2010.03.31
v-H-ras로 형질전환된 세포주에서 Spry2의 억제에 따른 Raf-1 kinase의 활성도 증가와 택솔 감수성의 연관성에 대한 연구, Molecular and Cellular Biochemistry , 제332권(집) , 제1호 , PP.189~197 , 2009.12.01
단기시험법을 이용한 치자황색소에 대한 유전독성연구, Molecular & Cellular Toxicology , 제5권(집) , 제3호 , PP.257~264 , 2009.09.01
정상세포주와 v-Ha-ras Transformed 세포주에서의 차이점에 대한 연구, Cancer Research and Treatment , 제41권(집) , 제2호 , PP.93~99 , 2009.06.30
정상간세포와 형질전환된 간세포에서 유전자발현 프로파일을 통한 아세타아미노펜에 대한 약물감수성 분석, Molecular & Cellular Toxicology , 제5권(집) , 제1호 , PP.32~43 , 2009.03.01
In vitro 단기시험법을 이용한 카라기난에 대한 유전독성 연구, Toxicological Research , 제25권(집) , 제1호 , PP.51~58 , 2009.03.01
In Vitro Studies on the Genotoxix Effects of Wood Smoke Flavors, 한국독성학회지 , 제24권(집) , 제3호 , PP.321~328 , 2008.12.01
Differential Psysiological Effects of Raf-1 Kinase Pathways Linked to Protein C Activation Depending on the Stimulus in v-H-ras-transformed Cells, 대한암학회지 , 제40권(집) , 제2호 , PP.39~44 , 2008.06.30
Evaluation of Genotoxicity of Water and Ethanol Extracts from Rhus verniciflua Stokes(RVS), 한국독성학회지 , 2008.06.01
Comparison of in Vitro Cell Transformation Assay Using Murine Fibroblasts and Human Keratinocytes, 한국독성학회지 , 제24권(집) , 제1호 , PP.37~44 , 2008.03.01
In vitro Assessment of Clastogenicity of Mobile-Phone Radiation(835MHz) Using the Alkline Comet Assay and Chromosonmal Aberration Test, Environmental Toxicology , 제23권(집) , 제3호 , PP.319~327 , 2008.01.30
Tyrosine phosphorylation and Ras activation is required for hydrogen peroxide-mediated Raf-1 kinase activation, Mol Cell Biochem , 제317권(집) , PP.121~129 , 2008.01.01
Toxicity of repeated intravenous injection of gene therapeutics for X-CGD in mice, Human & Experimental Toxicology , 제27권(집) , PP.401~407 , 2008.01.01
Overexpression of Human Raf-1 enhances radiosensitivity in fission yeast,Schiaosaccharomyeces pombe, Cell Biochemistry and Function , 2007.07.05
Human Raf-1 Proteins Associate With Rad 24 and Cdc25 in Cell-Cycle Checkpoint Pathway of Fission Yeast,Schizosaccharomyces pombe, Journal of Cellular Biochemistry , 제101권(집) , PP.488~497 , 2007.05.15
Diethylnitrosamine처리 후 병리학적 결과를 기초로 한 마우스 간에서의 유전자 발현 분석, J. Toxicol. Pub. Health , 제23권(집) , 제1호 , PP.55~63 , 2007.03.31
Genotoxicity Assessment of HM10620 Containing Recombinant Human Interferon-α, Drug and Chemical Toxicology , 제30권(집) , PP.83~95 , 2007.01.01
Validation of photo-comet assay as a model for the prediction of photocarcinogenicity, 한국독성학회지 , 제22권(집) , 제4호 , PP.423~429 , 2006.12.31
Raf-1 kinase activation is uncoupled from downstream MEK/ERK pathway in cells treated with Src tyrosine kinase inhibitor PP2, BBRC , 제350권(집) , 제2호 , PP.450~456 , 2006.11.17
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