교수소개

교수

심민석
직책/직급
교수
주전공
고분자공학, 약물 전달
담당과목
유기화학(1), 유기화학(2), 고분자공학, 나노의학, 나노바이오실험(2)
전화번호
032-835-8268
이메일
msshim@inu.ac.kr
홈페이지
https://sites.google.com/site/nanobiopolymers/
학력

2011.01.14 Case Western Reserve University  (공학박사)

2005.02.25 서울대학교  (공학사)

경력

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연구실적
<논문> 

Bioreducible exosomes encapsulating glycolysis inhibitors potentiate mitochondria-targeted sonodynamic cancer therapy via cancer-targeted drug release and cellular energy depletion, BIOMATERIALS , 2023.10.01

Exosome membrane-sheathed and multi-stimuli-responsive MnO2 nanoparticles with self-oxygenation and energy depletion abilities potentiate the sonodynamic therapy of hypoxic tumors, Chemical Engineering Journal , 제472권(집) , PP.144871~ , 2023.09.15

Brain endothelial cell-derived extracellular vesicles with a mitochondria-targeting photosensitizer effectively treat glioblastoma by hijacking the blood‒brain barrier, Acta Pharmaceutica Sinica B , 제13권(집) , 제9호 , PP.3834~3848 , 2023.09.01

Piezocatalytic 2D WS2 Nanosheets for Ultrasound-Triggered and Mitochondria-Targeted Piezodynamic Cancer Therapy Synergized with Energy Metabolism-Targeted Chemotherapy, ADVANCED MATERIALS , 제35권(집) , 제18호 , 2023.05.01

Mitochondria-targeting sonosensitizer-loaded extracellular vesicles for chemo-sonodynamic therapy, JOURNAL OF CONTROLLED RELEASE , 제354권(집) , PP.651~663 , 2023.02.01

Guanidinium-functionalized Block Copolyelectrolyte Micelleplexes for Safe and Efficient siRNA Delivery, BIOTECHNOLOGY AND BIOPROCESS ENGINEERING , 2022.12.01

Glutathione-depleted and cancer-targeted nanocapsules encapsulating bimetallic oxide nanoparticles for enhanced chemo-sonodynamic therapy, JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY , 제114권(집) , PP.171~180 , 2022.10.25

Extracellular vesicles with high dual drug loading for safe and efficient combination chemo-phototherapy, Biomaterials Science , 제10권(집) , 제11호 , PP.2817~2830 , 2022.05.31

Piezoelectric Au-decorated ZnO nanorods: Ultrasound-triggered generation of ROS for piezocatalytic cancer therapy, CHEMICAL ENGINEERING JOURNAL , 제435권(집) , 제3호 , PP.135039~ , 2022.05.01

Beyond hydrophilic polymers in amphiphilic polymer-based self-assembled NanoCarriers: Small hydrophilic carboxylate-capped disulfide drug delivery system and its multifunctionality and multispatial targetability, BIOMATERIALS , 제280권(집) , PP.121307~ , 2022.01.01

Pro-oxidant drug-loaded porphyrinic zirconium metal-organic-frameworks for cancer-specific sonodynamic therapy, COLLOIDS AND SURFACES B-BIOINTERFACES , 제209권(집) , 제1호 , PP.112189~ , 2022.01.01

Engineered extracellular vesicle-based sonotheranostics for dual stimuli-sensitive drug release and photoacoustic imaging-guided chemo-sonodynamic cancer therapy, Theranostics , 제12권(집) , 제3호 , PP.1247~1266 , 2022.01.01

Polysorbate-Based Drug Formulations for Brain-Targeted Drug Delivery and Anticancer Therapy, Applied Sciences-Basel , 제11권(집) , 제19호 , 2021.10.08

Metformin and Dichloroacetate Suppress Proliferation of Liver Cancer Cells by Inhibiting mTOR Complex 1, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , 제22권(집) , 제18호 , 2021.09.01

Gold nanorods-encapsulated thermosensitive drug carriers for NIR light-responsive anticancer therapy, JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY , 제98권(집) , PP.211~216 , 2021.06.25

3D-Printed Chitosan Composites for Biomedical Applications, Advances in Polymer Science , 제288권(집) , PP.87~116 , 2021.06.18

Safe and Targeted Sonodynamic Cancer Therapy Using Biocompatible Exosome-Based Nanosonosensitizers, ACS Applied Materials & Interfaces , 제13권(집) , 제22호 , PP.25575~25588 , 2021.06.09

Surface Roughness Effects of Pd-loaded Magnetic Microspheres on Reduction Kinetics of Nitroaromatics, BULLETIN OF THE KOREAN CHEMICAL SOCIETY , 제42권(집) , 제6호 , PP.894~899 , 2021.06.01

Efficient and selective cancer therapy using pro-oxidant drug-loaded reactive oxygen species (ROS)-responsive polypeptide micelles, JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY , 제95권(집) , PP.101~108 , 2021.03.25

Disrupting the Redox Balance with a Diselenide Drug Delivery System: Synergistic or Antagonistic? , ADVANCED FUNCTIONAL MATERIALS , 제31권(집) , 제6호 , PP.2007275~ , 2021.02.01

Solvent-driven, self-assembled acid-responsive poly(ketalized serine)/siRNA complexes for RNA interference, Biomaterials Science , 제8권(집) , 제23호 , PP.6718~6729 , 2020.12.07

Guanidinium-Incorporated Micelleplexes for Low Toxic and Efficient siRNA Delivery, MACROMOLECULAR RESEARCH , 제28권(집) , 제12호 , PP.1160~1165 , 2020.11.01

Non-ionic polysorbate-based nanoparticles for efficient combination chemo/photothermal/photodynamic therapy, JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY , 제88권(집) , PP.260~267 , 2020.08.25

Mitochondria-targeted drug delivery in cancers, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE , 제1866권(집) , 제8호 , PP.165808~ , 2020.08.01

Effects of Decomplexation Rates on Ternary Gene Complex Transfection with alpha-Poly(L-Lysine) or epsilon-Poly(L-Lysine) as a Decomplexation Controller in An Easy-To-Transfect Cell or A Hard-To-Transfect Cell, Pharmaceutics , 제12권(집) , 제6호 , PP.490~ , 2020.05.28

Microfluidic fabrication of fatty alcohol-based microparticles for NIR light-triggered drug release, JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY , 제80권(집) , PP.778~783 , 2019.12.25

Controlling complexation/decomplexation and sizes of polymer-based electrostatic pDNA polyplexes is one of the key factors in effective transfection, COLLOIDS AND SURFACES B-BIOINTERFACES , 제184권(집) , PP.110497~ , 2019.12.01

Pro-Oxidant Drug-Loaded Au/ZnO Hybrid Nanoparticles for Cancer-Specific Chemo-Photodynamic Combination Therapy , ACS Biomaterials Science & Engineering , 제5권(집) , 제10호 , PP.5209~5217 , 2019.10.01

ROS-responsive thioether-based nanocarriers for efficient pro-oxidant cancer therapy, JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY , 제75권(집) , PP.238~245 , 2019.07.25

Selective Anticancer Therapy Using Pro-Oxidant Drug-Loaded Chitosan-Fucoidan Nanoparticles, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , 제20권(집) , 제13호 , PP.3220~ , 2019.07.01

Glycol chitosan-coated near-infrared photosensitizer-encapsulated gold nanocages for glioblastoma phototherapy, Nanomedicine-Nanotechnology Biology and Medicine , 제18권(집) , PP.315~325 , 2019.06.01

Targeted siRNA delivery using aptamer-siRNA chimeras and aptamer-conjugated nanoparticles, Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology , 제11권(집) , 제e1543호 , 2019.05.01

Bioreducible polyspermine-based gene carriers for efficient siRNA delivery: Effects of PEG conjugation on gene silencing efficiency, MACROMOLECULAR RESEARCH , 제26권(집) , 제12호 , PP.1135~1142 , 2018.12.01

Microfluidic fabrication of biocompatible poly(N-vinylcaprolactam)-based microcarriers for modulated thermo-responsive drug release, COLLOIDS AND SURFACES B-BIOINTERFACES , 제172권(집) , PP.380~386 , 2018.12.01

Mitochondria-targeting drug conjugates for cytotoxic, anti-oxidizing and sensing purposes: current strategies and future perspectives, Acta Pharmaceutica Sinica B , 제8권(집) , PP.862~880 , 2018.10.01

Hydroxyapatite from Cuttlefish Bone: Isolation, Characterizations, and Applications, BIOTECHNOLOGY AND BIOPROCESS ENGINEERING , 제23권(집) , PP.383~393 , 2018.09.13

Cancer-targeted photothermal therapy using aptamer-conjugated gold nanoparticles, JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY , 제67권(집) , PP.429~436 , 2018.09.01

Photo-triggered antibacterial and anticancer activities of zinc oxide nanoparticles, Journal of Materials Chemistry B , 제6권(집) , 제30호 , PP.4852~4871 , 2018.08.14

Cancer-specific pro-oxidant therapy using low-toxic polypeptide micelles encapsulating piperlongumine, JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY , 제63권(집) , PP.57~64 , 2018.07.25

Studies on three-phase three-dimensional hybrid electrochemical reactor for treating textile effluent, DESALINATION AND WATER TREATMENT , 제116권(집) , PP.242~250 , 2018.06.30

Preparation, characterization and biological applications of biosynthesized silver nanoparticles with chitosan-fucoidan coating, MOLECULES , 제23권(집) , 제6호 , PP.1429~ , 2018.06.12

Fabrication of dual stimuli-responsive multicompartmental drug carriers for tumor-selective drug release , LAB ON A CHIP , 제18권(집) , 제4호 , PP.754~764 , 2018.03.07

Bioreducible polymer micelles based on acid-degradable poly(ethylene glycol)-poly(amino ketal) enhance the stromal cell-derived factor-1α gene transfection efficacy and therapeutic angiogenesis of human adipose-derived stem cells, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , 제19권(집) , 제2호 , PP.529~ , 2018.02.10

Chitosan as a vehicle for growth factor delivery: Various preparations and their applications in bone tissue regeneration, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 제104권(집) , PP.1383~1397 , 2017.09.19

Marine fish proteins and peptides for cosmeceuticals: A review, Marine Drugs , 제15권(집) , 제5호 , PP.143~ , 2017.05.19

Antimicrobial and anticancer activities of porous chitosan-alginate biosynthesized silver nanoparticles, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 제98권(집) , PP.515~525 , 2017.05.01

Antimicrobial, antioxidant, and anticancer activitiesof biosynthesized silver nanoparticles using marinealgae Ecklonia cava, Nanomaterials , 제6권(집) , 제12호 , PP.235~ , 2016.12.06

Preparation of piperlongumine-loaded chitosannanoparticles for safe and efficient cancer therapy, RSC Advances , 제6권(집) , 제83호 , PP.79307~79316 , 2016.08.22

Combination of nano-hydroxyapatite with stem cells for bone tissue engineering, JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY , 제16권(집) , 제9호 , PP.8881~8894 , 2016.08.02

Targeted and effective photodynamic therapy for cancer using functionalized nanomaterials, Acta Pharmaceutica Sinica B , 제6권(집) , 제4호 , PP.297~307 , 2016.07.18

Microfluidic Synthesis of pH-SensitiveMulticompartmental Microparticles for MultimodulatedDrug Release, Small , 제12권(집) , 제25호 , PP.3463~3470 , 2016.07.06

"Combo" nanomedicine: Co-delivery of multi-modal therapeutics forefficient, targeted, and safe cancer therapy, ADVANCED DRUG DELIVERY REVIEWS , 제98권(집) , PP.3~18 , 2016.03.01

Preparation and characterization of chitosan-natural nanohydroxyapatite-fucoidan nanocomposites for bone tissue engineering, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 제93권(집) , PP.1479~1487 , 2016.02.26

Seaweed Polysaccharide-Based Nanoparticles: Preparation and Applications for Drug Delivery, POLYMERS , 제8권(집) , 제2호 , PP.30~ , 2016.01.26

Engineered photo-responsive materials for near-infrared-triggered drug delivery, JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY , 제31권(집) , PP.15~25 , 2015.11.25

Stimuli-Responsive Materials for Controlled Release of Theranostic Agents, ADVANCED FUNCTIONAL MATERIALS , 제24권(집) , 제27호 , PP.4206~4220 , 2014.07.16

Nano-enabled drug delivery: A research profile, NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE , 제10권(집) , 제5호 , PP.889~896 , 2014.07.01

Synthetically designed peptide-based biomaterials with stimuli-responsive and membrane-active properties for biomedical applications, JOURNAL OF MATERIALS CHEMISTRY B , 제2권(집) , 제6호 , PP.595~615 , 2014.02.14

Nanoparticles with dual responses to oxidative stress and reduced pH for drug release and anti-inflammatory applications, ACS Nano , 제8권(집) , 제2호 , PP.1213~1221 , 2014.01.03

Stimuli-responsive siRNA carriers for efficient gene silencing in tumors via systemic delivery, BIOMATERIALS SCIENCE , 제2권(집) , 제1호 , PP.35~40 , 2014.01.01

A Reactive Oxygen Species (ROS)-Responsive Polymer for Safe, Efficient, and Targeted Gene Delivery in Cancer Cells, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION , 제52권(집) , 제27호 , PP.6926~6929 , 2013.02.28

A bioreducible polymer for efficient delivery of fas-silencing siRNA into stem cell spheroids and enhanced therapeutic angiogenesis, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION , 제51권(집) , 제47호 , PP.11899~11903 , 2012.11.19

Ketalized poly(amino ester) for stimuli-responsive and biocompatible gene delivery, Polymer Chemistry , 제3권(집) , 제9호 , PP.2570~2577 , 2012.09.01

Stimuli-responsive polymers and nanomaterials for gene delivery and imaging applications, ADVANCED DRUG DELIVERY REVIEWS , 제64권(집) , 제11호 , PP.1046~1059 , 2012.08.01

siRNA as a conventional drug in the clinic? Challenges and current technologies, Drug Discovery Today: Technologies , 제9권(집) , 제2호 , PP.167~173 , 2012.06.01

Dual mode polyspermine with tunable degradability for plasmid DNA and siRNA delivery, BIOMATERIALS , 제32권(집) , 제16호 , PP.4009~4020 , 2011.06.01

Efficient and targeted delivery of siRNA in vivo, FEBS JOURNAL , 제277권(집) , 제23호 , PP.4814~4827 , 2010.12.01

Dynamics of Nucleic Acid/Cationic Polymer Complexation and Disassembly Under Biologically Simulated Conditions Using In Situ Atomic Force Microscopy, MICROSCOPY RESEARCH AND TECHNIQUE , 제73권(집) , 제9호 , PP.845~856 , 2010.09.01

Combined Multimodal Optical Imaging and Targeted Gene Silencing Using Stimuli-Transforming Nanotheragnostics, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY , 제132권(집) , 제24호 , PP.8316~8324 , 2010.06.01

Acid-transforming polypeptide micelles for targeted nonviral gene delivery, BIOMATERIALS , 제31권(집) , 제12호 , PP.3404~3413 , 2010.04.01

<저서> 

Bone Response to Dental Implant Materials, Woodhead Publishing , 2016.10.28